Srimathveeravalli Research Group
Our group studies the interaction of non-ionizing energy and biology at multiscale resolution, from cells through organ systems. Computer simulations are used to model biological response evoked upon exposure to energy and to design energy parameters that elicit specific responses. We develop novel medical devices for energy delivery in vitro and in vivo, allowing identification of signaling pathways and cellular activity that is altered or upregulated upon energy-based treatment. Our techniques allow the targeted modulation of barrier function in the tissue microenvironment (cell membrane, stroma and blood vessels), creating new platforms for the study of cancer and other diseases. The knowledge gained from our experiments has applications in tumor ablation, drug delivery, immunotherapy and tissue engineering. We emphasize rapid translation of our findings to the clinic through collaboration and involving physicians and other key stakeholders at all stages of our research.
We are looking for motivated undergraduate and graduate students, as well as postdoctoral scholars who are interested in energy based therapies and medical devices. The ideal candidate will be interested in performing impactful computational and experimental research as part of a multidisciplinary research team comprised of engineers, biomedical researchers, and physicians. Familiarity with numerical modeling techniques, Matlab, and CAD software is desirable. Prior experience performing in-vitro studies and a basic understanding of biology will be a plus. Interested candidates should contact Dr. Srimathveeravalli through email with a one page resume, and a summary of research interests and career goals.
The Srimathveeravalli Research Lab is supported by the National Institutes of Health under award number R01CA236615 and R01DK129990, the Dept. of Defense CDMRP awards CA170630 and CA190888, the Institute for Applied Life Sciences, M2M Midigrant and the Dept. of Mechanical and Industrial Engineering.
Our lab is located at: N540 Life Sciences Building, 240 Thatcher Way, University of Massachusetts at Amherst, MA 01003.